Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC2467
Trial ID NCT04563702
Disease COVID-19
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-CoV2-1
PhasePhase1
Recruitment statusCompleted
TitleA Phase 1 Open-Label, Dose-Ranging Trial to Determine the Safety and Immunogenicity of an Adenoviral-Vector Based Vaccine (VXA-CoV2-1) Expressing a SARS-CoV-2 Antigen and dsRNA Adjuvant Administered Orally to Healthy Adult Volunteers VXA-CoV2-1.1-S Boost Substudy: Boost at 1 Year Post Initial Vaccination With an Adenoviral-Vector Based Vaccine VXA-CoV2-1.1-S Expressing a SARS-CoV-2 S Protein in a Subset of Subjects
Year2020
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA-COV2-101
Vector information
Vectoradenovirus
Transgene/Inserted genethe full-length SARS-CoV-2 stabilized S protein coding sequences; dsRNA adjuvant
Regulatory elementthe cytomegalovirus (CMV) promoter

Clinical Result

Cohort1: VXA-CoV2-1_dose level 1
Administration route oral
Dosage VXA-CoV2-1, 1E10 IU
Age Adult
References PMID: 35511920
Cohort2: VXA-CoV2-1_dose level 2
Administration route oral
Dosage VXA-CoV2-1, 1E11 IU
Age Adult
References PMID: 35511920

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