Basic Information

Gene symbol GPRC5D Synonyms None Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description G protein-coupled receptor class C group 5 member D

GTO ID GTC2460
Trial ID NCT04555551
Disease Multiple Myeloma
Altered gene GPRC5D
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MCARH109
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleMCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of Multiple Myeloma
Year2020
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)18-367
Vector information
Vectorlentivirus
Transgene/Inserted genehuman B-cell-derived GPRC5D single-chain variable fragment; 4-1BB costimulatory domain; CD3ζ signaling domain

Clinical Result

Cohort 1
Administration route None
Dosage 25E6 cells, 50E6 cells, 150E6 cells, 450E6 cells
Pts 17
Age Adult, Older_Adult
Adverse reactions 1/17(CRS; ICANS)
References PMID: 36170501

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