Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2450
Trial ID NCT04539444
Disease Non-Hodgkin's Lymphoma
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
Co-treatment Tislelizumab
PhasePhase2
Recruitment statusUnknown
TitleA Study of CD19/22 cells Combined With PD-1 Inhibitor in Relapsed/Refractory B-cell Lymphoma
Year2020
CountryChina
Company sponsorThe First Affiliated Hospital of Soochow University
Other ID(s)CCPD-1 in lymphoma

Clinical Result

Cohort 1
Administration route None
Dosage 0.5~2E7 cells/kg
Pts 16
Age Adult, Older_Adult
Outcome 11/16(CR). The 1-year progression-free survival and overall survival rates were 68.8% and 81.3%, respectively.
Adverse reactions No neurologic adverse events were reported.
References PMID: 37776326

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