Basic Information


GTO ID GTC2445
Trial ID NCT04536922
Disease Anal Squamous Cell Carcinoma
Altered gene Neoantigen
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Neoantigen TCR-T cells
Co-treatment Pembrolizumab
HLAunspecified
PhasePhase2
Recruitment statusWithdrawn
TitleSingle Patient Protocol: A Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
Year2020
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)10000163|000163-C
Vector information
Vectorretrovirus

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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