Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2439
Trial ID NCT04531046
Disease B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Generation2nd
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleAxi-Cel as a 2nd Line Therapy in Patients With Relapsed/Refractory Aggressive B Lymphoma Ineligible to Autologous Stem Cell Transplantation
Year2020
CountryBelgium
Company sponsorThe Lymphoma Academic Research Organisation
Other ID(s)ALYCANTE
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E6 cells/kg
Donor type Autologous
Pts 40
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 31/40(CR); 75%(ORR, at 3 month); 15/40(SD)
Adverse reactions 14/40(prolonged cytopenias)
References DOI: 10.1182/blood-2022-156626

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