Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC2435
Trial ID NCT04526509
Disease Lung Non-Small Cell Carcinoma | Synovial Sarcoma | Myxoid Liposarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment GSK3901961
HLAHLA-A*02:01
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleMaster Protocol to Assess the Safety and Recommended Phase 2 Dose of Next Generations of Autologous Enhanced NY-ESO-1/ LAGE-1a TCR Engineered T-cells, Alone or in Combination With Other Agents, in Participants With Advanced Tumors
Year2020
CountryUnited States
Company sponsorGlaxoSmithKline
Other ID(s)209012|2019-004446-14

Clinical Result

Cohort1: GSK3901961_NSCLC
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: GSK3901961_SS/MRCLS
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: GSK3845097_SS/MRCLS
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort4: GSK4427296_SS/MRCLS
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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