Basic Information


GTO ID GTC2433
Trial ID NCT04520711
Disease Epithelial Cancer
Altered gene Neoantigen
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Neoantigen TCR-T cells
HLAunspecified
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleHotspot TCR-T: A Phase I/Ib Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T) Targeting Tumor-Specific Neoantigens, With in Vivo CD40 Activation and PD-1 Blockade, for Patients With Incurable Cancers (2020000584)
Year2020
CountryUnited States
Company sponsorProvidence Health & Services
Other ID(s)2020000584
Vector information
Vectorretrovirus

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.1~1E10 cells
Donor type autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes

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