Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2430
Trial ID NCT04516551
Disease B-Cell Leukemia | B-Cell Lymphoma | Recurrent Adult Acute Lymphocytic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1
Recruitment statusUnknown
TitleAnti-CD19 Allo-CAR-T Cells for Relapsed B Cell Malignancies After HSCT
Year2020
CountryChina
Company sponsorXinqiao Hospital of Chongqing
Other ID(s)Anti-CD19 allo-CAR-T

Clinical Result

Cohort 1
Administration route None
Dosage 3E6 cells/kg, 6E6 cells/kg, 1E7 cells/kg
Donor type Allogeneic
Pts 9
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 9/9(CR at 28 dyas). The overall response rates (ORR) were 100% (9/9), 88.9% (8/9), and 75% (6/8) at 3 month, 6 month, and 12 month, respectively. The 1-year progression-free and overall survival were 77.8% and 85.7%, respectively.
Adverse reactions Three patients had acute graft-versus-host-disease (grade I, n = 1; grade II, n = 1; grade IV, n = 1) and all resolved after treatment.
References PMID: 38204488

Relationship Graph

Overview of Knowledge Graph