Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2426
Trial ID NCT04512716
Disease Diffuse Large B-Cell Lymphoma | B-Cell Acute Lymphoblastic Leukemia | Diffuse Large B-Cell Lymphoma Activated B-Cell Type | Non-Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleIomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma
Year2020
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)20-382

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg, 2E6 cells/kg, single infusion
Pts 6
Age Adult, Older_Adult

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