Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC2425
Trial ID NCT04511871
Disease Ovarian Cancer | Breast Cancer | Stomach Cancer | Sarcoma | Solid Tumor
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CCT303-406
PhasePhase1
Recruitment statusRecruiting
TitleA Phase I Trial of CCT303-406 in Patients With Relapsed or Refractory HER2 Positive Solid Tumors
Year2020
CountryChina
Company sponsorShanghai PerHum Therapeutics Co., Ltd.
Other ID(s)CCT303-406-mST01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3E5 cells/kg, 1E6 cells/kg, 1E7 cells/kg
Donor type Autologous
Pts 15
Age Adult, Older_Adult
Lymph depletion Yes

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