Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2414
Trial ID NCT04499573
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleBispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B-ALL
Year2020
CountryRussian Federation
Company sponsorFederal Research Institute of Pediatric Hematology, Oncology and Immunology
Other ID(s)NCPHOI-2020-07

Clinical Result

Cohort1: autologous lymphocytes
Administration route None
Dosage 0.15~1.5E6 cells/kg
Donor type Autologous|Allogeneic
Age Child, Adult
Cohort2: allogeneic lymphocytes
Administration route None
Dosage 0.1E6 cells/kg
Donor type Autologous|Allogeneic
Age Child, Adult

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