Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2407
Trial ID NCT04484012
Disease Mantle Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Co-treatment Acalabrutinib
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleModified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Year2020
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)19405|NCI-2020-04550|19405|P30CA033572

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 8
Age Adult, Older_Adult
Outcome 6/8(CR); 1/8(PR); 88%(ORR)
Adverse reactions no serious adverse events
References : 4840 CD19-Directed CAR T-Cells (CD19-CAR) Combined with Acalabrutinib Achieves Durable Remissions in Patients with Relapsed or Refractory (r/r) Mantle Cell Lymphoma (MCL)

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