Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD276 Synonyms 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 Type of gene protein-coding
Description CD276 molecule

GTO ID GTC2406
Trial ID NCT04483778
Disease Pediatric Solid Tumor | Germ Cell Tumor | Hepatoblastoma | Rhabdoid Tumor | Carcinoma | Melanoma | Neuroblastoma | Ewing Sarcoma | Rhabdomyosarcoma | Clear Cell Sarcoma | Childhood Soft Tissue Sarcoma | Retinoblastoma | Synovial Sarcoma | Peripheral Nerve Sheath Neoplasm | Osteosarcoma | Desmoplastic Small Round Cell Tumor
Altered gene CD276|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment SCRI-CARB7H3(s)|SCRI-CARB7H3(s)x19
Co-treatment pembrolizumab
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleB7-H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults
Year2020
CountryUnited States
Company sponsorSeattle Children's Hospital
Other ID(s)STRIvE-02
Vector information
Vectorlentivirus
ConstructscFV-IgG4hinge-CD28tm-4-1BB-zeta B7H3
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route None
Pts 16
Age Child, Adult
Outcome 3/9(SD)
Adverse reactions 2/9(CRS, grade 2)
References DOI: 10.1200/JCO.2022.40.16_suppl.10011

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