Basic Information


GTO ID GTC2399
Trial ID NCT04464889
Disease Multiple Myeloma | Malignant Lymphoma | Leukemia | Myelodysplastic Syndrome | Myelofibrosis
Altered gene HA-1H
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MDG1021
HLAHLA-A*02:01
PhasePhase1
Recruitment statusWithdrawn
TitleA Dose-Escalation, Open Label Phase I Study to Assess the Safety, Feasibility and Preliminary Efficacy of HA-1H TCR Modified T Cells, MDG1021, in Patients With Relapsed or Persistent Hematologic Malignancies After Allogeneic HSCT With or Without Unmanipulated DLI
Year2020
CountryNetherlands
Company sponsorMedigene AG
Other ID(s)CD-TCR-003

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 0.3E6 cells
Donor type autologous
Age Adult, Older_Adult
Lymph depletion No
Cohort2: dose level 2
Administration route infusion
Dosage 1E6 cells
Donor type autologous
Age Adult, Older_Adult
Lymph depletion No
Cohort3: dose level 3
Administration route infusion
Dosage 3E6 cells
Donor type autologous
Age Adult, Older_Adult
Lymph depletion No

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