Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2398
Trial ID NCT04464200
Disease Chronic Lymphocytic Leukemia | Waldenstrom Macroglobulinemia | Marginal Zone Lymphoma | Burkitt Lymphoma | Primary Mediastinal B-Cell Lymphoma | Non-Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma Activated B-Cell Type
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment 19(T2)28z1xx CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
Title19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers
Year2020
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)20-167

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 25E6 cells, 50E6 cells, 100E6 cells, 200E6 cells; de~escalation dose: 12.5E6 cells
Pts 30
Age Adult, Older_Adult
References DOI: 10.1182/blood-2023-187623

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