Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2382
Trial ID NCT04432506
Disease Primary Mediastinal B-Cell Lymphoma | Non-Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma | B-Cell Lymphoma | Hematopoietic and Lymphoid Cell Neoplasm | Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment Anakinra
Generation2nd
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleAnakinra for the Reduction of CAR-T Toxicity in Patients With Relapsed or Refractory Large B-cell Lymphoma
Year2020
CountryUnited States
Company sponsorM.D. Anderson Cancer Center
Other ID(s)2019-1051|NCI-2020-04369|2019-1051
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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