Basic Information

Gene symbol ICAM1 Synonyms BB2, CD54, P3.58 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description intercellular adhesion molecule 1

GTO ID GTC2374
Trial ID NCT04420754
Disease Recurrent Parathyroid Cancer | Thyroid Cancer
Altered gene ICAM1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment AIC100
PhasePhase1
Recruitment statusRecruiting
TitleStudy of AIC100 CAR T Cells in Relapsed/Refractory Thyroid Cancer
Year2020
CountryUnited States
Company sponsorAffyImmune Therapeutics, Inc.
Other ID(s)19-12021154

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 1E6 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 2
Administration route None
Dosage 1E7 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 3
Administration route None
Dosage 1E8 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort4: dose level 4
Administration route None
Dosage 5E8 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort5: dose level 5
Administration route None
Dosage 2.5E8 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort6: dose level 6
Administration route None
Dosage 7.5E8 cells
Donor type Autologous
Age Adult, Older_Adult
Lymph depletion Yes

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