Basic Information


GTO ID GTC2360
Trial ID NCT04406272
Disease Glioblastoma
Altered gene TNFR1::Fas
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment VB111|ofranergene obadenovec
Co-treatment Surgery|Bevacizumab
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Randomized, Controlled Phase II Surgical Trial to Evaluate Early Immunologic Pharmacodynamic Parameters for the Viral Cancer Therapy Ofranergene Obadenovec (VB-111) in Patients With Surgically Accessible Recurrent/Progressive Glioblastoma
Year2020
CountryUnited States
Company sponsorDana-Farber Cancer Institute
Other ID(s)19-792
Vector information
Vectoradenovirus
ConstructAd5-PPE-1-3X-TNFR1::Fas
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genea Fas-TNFR1 chimeric pro-apoptotic protein
Regulatory elementa proprietary modified murine pre-endothelin 1 promoter (PPE-1-3X)

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 15
Age Adult, Older_Adult
References PMID: 32265057

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