Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2343
Trial ID NCT04340154
Disease Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhasePhase2
Recruitment statusRecruiting
TitleStudy of Sequential CAR-T Cell Treating Leukemia Children
Year2020
CountryChina
Company sponsorBeijing Boren Hospital
Other ID(s)BR-1922-C

Clinical Result

Cohort 1
Administration route None
Pts 81
Age Child, Adult
Lymph depletion Yes
Outcome 97%(ORR)
Adverse reactions 64/81(cytopenias); 15/81(cytokine release syndrome); 4/81(neurotoxicity); 5/81(infections)
References PMID: 37863088

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