Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2339
Trial ID NCT04322292
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment C-CAR088
PhasePhase1
Recruitment statusUnknown
TitleA Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
Year2019
CountryChina
Company sponsorInstitute of Hematology & Blood Diseases Hospital
Other ID(s)QT-2019007-EC-2
Vector information
Vectorlentivirus
Transgene/Inserted genescFv of C-CAR088, derived from a human IgG1 antibody; 4-1BB; CD3ζ

Clinical Result

Cohort1: low dose
Administration route None
Dosage 1~3E6 cells/kg
Donor type Autologous
Age Adult, Older_Adult
References PMID: 36100310
Cohort2: medium dose
Administration route None
Dosage 3~6E6 cells/kg
Donor type Autologous
Age Adult, Older_Adult
References PMID: 36100310
Cohort3: high dose
Administration route None
Dosage 6~9E6 cells/kg
Donor type Autologous
Age Adult, Older_Adult
References PMID: 36100310

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