Basic Information

Gene symbol IL3RA Synonyms CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra Type of gene protein-coding
Description interleukin 3 receptor subunit alpha

GTO ID GTC2338
Trial ID NCT04318678
Disease Blastic Plasmacytoid Dendritic Cell Neoplasm | B-Cell Acute Lymphoblastic Leukemia | T-Cell Acute Lymphoblastic Leukemia | Acute Myeloid Leukemia
Altered gene CD123
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD123 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleCD123-Directed Autologous T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)
Year2020
CountryUnited States
Company sponsorSt. Jude Children's Research Hospital
Other ID(s)CATCHAML

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3E5/kg, 1E6 cells/kg, 3E6 cells/kg, 1E7 cells/kg
Donor type Autologous
Pts 32
Age Child, Adult
Lymph depletion Yes

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