Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2332
Trial ID NCT04309981
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ARI0002h
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleClinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors, Immunomodulators and Anti-CD38 Antibody.
Year2020
CountrySpain
Company sponsorInstitut d'Investigacions Biomèdiques August Pi i Sunyer
Other ID(s)CARTBCMA-HCB-01|2019-001472-11
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted gene4-1BB co-stimulatory region; signal-transduction CD3z

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 36
Age Adult, Older_Adult
Outcome 15/30(CR); 15/30(PR)
Adverse reactions 20/30(cytopenias); 20/30(Infections)
References PMID: 37414060

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