Basic Information

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC2323
Trial ID NCT04288726
Disease Hodgkin's Lymphoma | Nasal Type Extranodal NK/T-Cell Lymphoma
Altered gene CD30
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD30.CAR-EBVST
PhasePhase1
Recruitment statusRecruiting
TitleAllogeneic CD30.CAR-EBVSTs in Patients With Relapsed or Refractory CD30-Positive Lymphomas
Year2020
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-46862 BESTA

Clinical Result

Cohort 1
Administration route None
Dosage 4E7 cells, 1E8 cells, 4E8 cells
Donor type Allogeneic
Pts 14
Age Child, Adult, Older_Adult
Outcome 5/10(CR); 4/13(PR); 69.2%(ORR)
Adverse reactions 2/14(reversible grade 4 cytopenia)
References DOI: 10.1182/blood-2022-160244

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