Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2316
Trial ID NCT04276870
Disease B-Cell Acute Lymphoblastic Leukemia | Central Nervous System Relapse | Childhood T-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Murine CD19 CAR-T cells
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleOrphan Indications for CD19 Redirected Autologous T Cells
Year2020
CountryUnited States
Company sponsorStephan Grupp MD PhD
Other ID(s)834653, 19CT023, 19-016979
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E6 cells/kg
Donor type Autologous
Pts 81
Age Child, Adult

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