Basic Information

Gene symbol IGK Synonyms IGK@ Type of gene protein-coding
Description immunoglobulin kappa locus

GTO ID GTC2284
Trial ID NCT04223765
Disease Splenic Marginal Zone Lymphoma | Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue | Non-Hodgkin's Lymphoma | Mantle Cell Lymphoma | Nodal Marginal Zone Lymphoma | Follicular Lymphoma
Altered gene IGK
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Kappa CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleStudy of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
Year2020
CountryUnited States
Company sponsorUNC Lineberger Comprehensive Cancer Center
Other ID(s)LCCC 1811-ATL

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E5 cells/kg, 1E6 cells/kg, 2E6 cells/kg
Donor type Autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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