Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2277
Trial ID NCT04205838
Disease Diffuse Large B-Cell Lymphoma | B-Cell Lymphoma | Primary Mediastinal B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment Anakinra
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleAnakinra in Preventing Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome in Patients With Recurrent or Refractory Large B-cell Lymphoma
Year2019
CountryUnited States
Company sponsorJonsson Comprehensive Cancer Center
Other ID(s)19-000604|NCI-2019-02887|19-000604
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 36
Age Adult, Older_Adult
Lymph depletion Yes

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