Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2276
Trial ID NCT04204161
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment AUTO3
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleA Clinical Study of CAR-T Cells Treatment for Children With CD19+/CD22+ R/R ALL and Lymphoma
Year2019
CountryChina
Company sponsorShenzhen BinDeBio Ltd.
Other ID(s)2019XY-BDB011

Clinical Result

Cohort 1
Administration route None
Dosage 1E5 cells/kg~2.5E8 cells/kg
Donor type Autologous
Pts 30
Age Child, Adult
Lymph depletion Yes

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