Basic Information


GTO ID GTC2271
Trial ID NCT04196413
Disease Brain Glioma | Spinal Cord Glioma
Altered gene GD2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GD2 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleGD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Year2020
CountryUnited States
Company sponsorStanford University
Other ID(s)IRB-52934|PEDSCCT6005|NCI-2020-05891
Vector information
Vectorretrovirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: Intravenously
Administration route intravenous infusion
Dosage 3E5 cells/kg (± 20%), 1E6 cells/kg (± 20%), 3E6 cells/kg (± 20%)
Donor type Autologous
Age Child, Adult
Lymph depletion Yes/No
Cohort2: Intracerebroventricularly_no lymphodepletion
Administration route intracerebroventricular injection
Dosage 10E6 cells (±20%), 30E6 cells (±20%), 50E6 cells (±20%), 100E6 cells (±20%)
Donor type Autologous
Age Child, Adult
Cohort3: Intracerebroventricularly_lymphodepletion
Administration route intracerebroventricular injection
Dosage 10E6 cells (±20%), 30E6 cells (±20%), 50E6 cells (±20%)
Donor type Autologous
Age Child, Adult

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