Basic Information

Gene symbol GRB2 Synonyms ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description growth factor receptor bound protein 2

GTO ID GTC2270
Trial ID NCT04196257
Disease Endometrial Cancer | Epithelial Ovarian Cancer | Fallopian Tube Neoplasm | Peritoneal Carcinoma
Altered gene GRB2
Therapeutic/Target gene Target gene
TherapyASO
Treatment BP1001|Liposomal Grb2 Antisense Oligonucleotide|Liposomal Grb-2|L-Grb-2
PhasePhase1
Recruitment statusRecruiting
TitleA Phase I/Ib Study of BP1001-A (a Liposomal Grb2 Antisense Oligonucleotide) in Patients With Advanced or Recurrent Solid Tumors
Year2022
CountryUnited States
Company sponsorBio-Path Holdings, Inc.
Other ID(s)BP1001-A-101-GynOnc
Vector information
Vectorliposome

Clinical Result

Cohort1: BP1001-A
Administration route intravenous injection
Dosage BP1001-A, dose escalation, twice weekly for 4 weeks (28-day cycle) for 6 cycles
Age Adult, Older_Adult
Cohort2: BP1001-A_paclitaxel
Administration route intravenous injection
Dosage BP1001-A, dose expansion, twice weekly for 4 weeks (28-day cycle) for 6 cycles|paclitaxel, twice weekly for 4 weeks (28-day cycle) for 6 cycles
Age Adult, Older_Adult

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