Basic Information

Gene symbol E6 Synonyms None Type of gene protein-coding
Description protein E6*;transforming protein E6

Gene symbol E7 Synonyms None Type of gene protein-coding
Description transforming protein E7

GTO ID GTC2260
Trial ID NCT04180215
Disease Squamous Cell Carcinoma
Altered gene E6|E7
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment HB-201
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase I/II Study of TheraT Vector(s) Expressing Human Papillomavirus 16 Positive (HPV 16+) Specific Antigens in Patients With HPV 16+ Confirmed Cancers
Year2019
CountryNetherlands|Spain|United States
Company sponsorHookipa Biotech GmbH
Other ID(s)H-200-001|2019-000907-34
Vector information
Vectoradenovirus
Constructad-E6/E7
Vector typeadenoviral vector
Transgene/Inserted genehuman papillomavirus 16 positive (HPV 16+) specific E7 and E6 antigens

Clinical Result

Cohort 1
Administration route intravenous infusion
Age Adult, Older_Adult
References DOI: 10.1200/JCO.2020.38.15_suppl.TPS3171

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