Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2255
Trial ID NCT04171843
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PBCAR269A
Co-treatment nirogacestat
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
Year2020
CountryUnited States
Company sponsorPrecision BioSciences, Inc.
Other ID(s)PBCAR269A-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 6E5~6E6 cells/kg
Pts 48
Age Adult, Older_Adult
Lymph depletion Yes

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