Basic Information

Gene symbol EPCAM Synonyms Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, LYNCH8, M4S1, MIC18, MK-1, MOC-31, TACSTD1, TROP1 Type of gene protein-coding
Description epithelial cell adhesion molecule

Gene symbol TM4SF1 Synonyms H-L6, L6, M3S1, TAAL6 Type of gene protein-coding
Description transmembrane 4 L six family member 1

GTO ID GTC2228
Trial ID NCT04151186
Disease Neoplasm
Altered gene TM4SF1|EpCAM
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TM4SF1/EpCAM CAR-T cells
Recruitment statusUnknown
TitleA Clinical Study on the Safety and Efficacy of CAR-T Therapy for the TM4SF1- and EpCAM-positive Solid Tumors
Year2019
CountryChina
Company sponsorTang-Du Hospital
Other ID(s)CART-TM4SF1/CART-EpCAM-CAN-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2~2.5E6 cells/kg, 4~5E6 cells/kg, 8~10E6 cells/kg
Pts 72
Age Adult, Older_Adult

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