Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2227
Trial ID NCT04150913
Disease Non-Hodgkin's Lymphoma | Neurotoxicity Syndromes
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment anakinra
Generation2nd
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity
Year2019
CountryUnited States
Company sponsorMassachusetts General Hospital
Other ID(s)19-348
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 15
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph