Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2224
Trial ID NCT04146051
Disease Myasthenia Gravis
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment DesCAR-Tes 08
PhasePhase2
Recruitment statusRecruiting
TitleDescartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
Year2019
CountryCanada
Company sponsorCartesian Therapeutics
Other ID(s)MG-001

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 30
Age Adult, Older_Adult
Outcome Mean improvements from baseline to week 12 were -6 (95% CI -9 to -3) for MG-ADL score, -7 (-11 to -3) for Quantitative Myasthenia Gravis score, -14 (-19 to -9) for Myasthenia Gravis Composite score, and -9 (-15 to -3) for Myasthenia Gravis Quality of Life 15-revised score.
References PMID: 37353278

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