Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2210
Trial ID NCT04129099
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GC022F
PhaseEarly_Phase1
Recruitment statusUnknown
TitleA Study of GC022F CAR-T Cell Immunotherapy for Relapsed or Refractory B- ALL
Year2019
CountryChina
Company sponsorHebei Yanda Ludaopei Hospital
Other ID(s)PGC0006

Clinical Result

Cohort 1
Administration route None
Dosage 6E4~1.5E5 cells/kg
Pts 9
Age Child, Adult, Older_Adult
Outcome 6/9(CR)
Adverse reactions no observed grade ≥ 3 cytokine release syndrome (CRS) and neurotoxicity in all patients.
References DOI: 10.1182/blood-2020-136866

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