Basic Information

Gene symbol IL1R1 Synonyms CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 1 receptor type 1

GTO ID GTC2202
Trial ID NCT04119687
Disease Osteoarthritis
Altered gene IL-1Ra
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment FX201|humantakinogene hadenovec
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleAn Open-Label, Single Ascending Dose Study to Assess the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee
Year2019
CountryUnited States
Company sponsorFlexion Therapeutics, Inc.
Other ID(s)FX201-2019-001
Vector information
Vectoradenovirus
ConstructHDAd-ratIL-1Ra
Transgene/Inserted geneinterleukin-1 receptor antagonist (IL-1Ra) gene
Regulatory elementan inflammation-sensitive promoter

Clinical Result

Cohort 1
Administration route injection
Age Adult, Older_Adult
References PMID: 34963343

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