Basic Information

Gene symbol IL3RA Synonyms CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra Type of gene protein-coding
Description interleukin 3 receptor subunit alpha

GTO ID GTC2199
Trial ID NCT04109482
Disease Blastic Plasmacytoid Dendritic Cell Neoplasm
Altered gene CD123
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MB-102
Generation2nd
PhasePhase1|Phase2
Recruitment statusTerminated
TitleTrial to Evaluate the Safety and Efficacy of MB-102 in Patients With BPDCN.
Year2019
CountryUnited States
Company sponsorMustang Bio
Other ID(s)MB102-CD123-001
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route None
Dosage 600E6 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes

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