Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2183
Trial ID NCT04088890
Disease Diffuse Large B-Cell Lymphoma | B-Cell Non-Hodgkin's Lymphoma | Follicular Lymphoma | B-Cell Acute Lymphoblastic Leukemia
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD22 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleAutologous CD22 CAR T Cells in Adults w/ Recurrent or Refractory B Cell Malignancies
Year2019
CountryUnited States
Company sponsorStanford University
Other ID(s)IRB-50836|CCT5029|IRB-50836
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage ALL: 3E5 cells/kg (± 20%); B~cell NHL: 1E6 cells/kg (± 20%), 3E6 cells/kg (± 20%), 1E7 cells/kg (± 20%)
Donor type Autologous
Pts 92
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph