Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2152
Trial ID NCT04034446
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhaseEarly_Phase1
Recruitment statusActive, Not Recruiting
TitleCD19-CD22 Chimeric Antigen Receptor T (CAR-T) Cell for Treatment of B Cell Acute Lymphoblastic Leukemia (B-ALL)
Year2019
CountryChina
Company sponsorInstitute of Hematology & Blood Diseases Hospital
Other ID(s)HY004001

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.5~3E6 cells/kg, maximum dose: 4E8 cells
Donor type Autologous
Pts 2
Age Child, Adult, Older_Adult

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