Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2149
Trial ID NCT04029038
Disease Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleModified Immune Cells (CD19-CD22 CAR T Cells) in Treating Patients With Recurrent or Refractory CD19 Positive, CD22 Positive Leukemia or Lymphoma
Year2020
CountryUnited States
Company sponsorM.D. Anderson Cancer Center
Other ID(s)2019-0042|NCI-2019-04229|2019-0042|P30CA016672

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 30
Age Child, Adult, Older_Adult
Lymph depletion Yes

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