Basic Information

Gene symbol MUC1 Synonyms ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mucin 1, cell surface associated

GTO ID GTC2146
Trial ID NCT04020575
Disease Sporadic Breast Cancer
Altered gene MUC1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment huMNC2-CAR44|huMNC2-CAR22
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleAutologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)
Year2020
CountryUnited States
Company sponsorMinerva Biotechnologies Corporation
Other ID(s)10038
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 69
Age Adult, Older_Adult

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