Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC2136
Trial ID NCT04007978
Disease B-Cell Lymphoma | Acute Lymphoblastic Leukemia
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD22 CAR-T cells
Generation3rd
PhasePhase1
Recruitment statusUnknown
TitleAnti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies
Year2019
CountryChina
Company sponsorWuhan Union Hospital, China
Other ID(s)WHUH-CART-CD22-01
Vector information
Vectorlentivirus
ConstructscFv-CD28-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Pts 50
Age Child, Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph