Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2132
Trial ID NCT04002401
Disease Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment rituximab
Generation2nd
PhasePhase2
Recruitment statusCompleted
TitleSafety and Efficacy of Axicabtagene Ciloleucel in Combination With Rituximab in Participants With Refractory Large B-Cell Lymphoma
Year2019
CountryUnited States
Company sponsorKite, A Gilead Company
Other ID(s)KT-US-471-0114|2019-004803-11
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E6 cells/kg
Donor type Autologous
Pts 27
Age Adult, Older_Adult
Lymph depletion Yes

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