Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC2121
Trial ID NCT03967223
Disease Myxoid Liposarcoma | Synovial Sarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Letetresgene autoleucel|GSK3377794|Lete-cel
HLAHLA-A*02:01|HLA-A*02:05|HLA-A*02:06
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleMaster Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered NY-ESO-1-Specific (c259) T Cells, Alone or in Combination With Other Agents, in HLA-A2+ Participants With NY-ESO-1 and/or LAGE-1a Positive Solid Tumors (IGNYTE-ESO)
Year2019
CountryUnited States
Company sponsorGlaxoSmithKline
Other ID(s)208467

Clinical Result

Cohort1: untreated advanced SS or MRCLS
Administration route infusion
Donor type autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes
Cohort2: advanced SS or MRCLS post anthracycline chemo
Administration route infusion
Donor type autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph