Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2116
Trial ID NCT03954106
Disease Neurotoxicity Syndromes | Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment defibrotide
Generation2nd
PhasePhase2
Recruitment statusTerminated
TitleA Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated Neurotoxicity
Year2019
CountryUnited States
Company sponsorJazz Pharmaceuticals
Other ID(s)JZP395-201
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 25
Age Adult, Older_Adult
Lymph depletion Yes

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