Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2103
Trial ID NCT03938987
Disease Acute Monocytic Leukemia | Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleAnti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
Year2020
CountryCanada
Company sponsorUniversity of Alberta
Other ID(s)ACIT001/EXC002
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 0.5E6 cells/kg, 1E6 cells/kg, 2E6 cells/kg
Donor type Autologous
Pts 63
Age Child, Adult, Older_Adult
Lymph depletion Yes

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