Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC2092
Trial ID NCT03915184
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CT053|zevorcabtagene autoleucel|zevor-cel
Location approved China
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleClinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
Year2019
CountryChina
Company sponsorCARsgen Therapeutics Co., Ltd.
Other ID(s)CT053-MM-02 (LUMMICAR STUDY 2)

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 14
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 4/10(CR), 6/10(PR)
Adverse reactions All subjects experienced ≥ grade 3 neutropenia (100%) and leukopenia (100%), and 36% of subjects had ≥ grade 3 thrombocytopenia within 30 days of treatment.
References DOI: 10.1182/blood-2020-139802

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