Basic Information


GTO ID GTC2083
Trial ID NCT03897881
Disease Melanoma
TherapymRNA vaccine
Treatment mRNA-4157
Co-treatment Pembrolizumab
PhasePhase2
Recruitment statusRecruiting
TitleA Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (KEYNOTE- 942)
Year2019
CountryUnited States|Australia
Company sponsorModernaTX, Inc.
Other ID(s)mRNA-4157-P201
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: mRNA-4157_Pembrolizumab
Administration route intravenous infusion
Dosage mRNA-4157, every 21 days, up to 9 doses
Pts 104
Age Adult, Older_Adult
References PMID: 38246194
Cohort2: Pembrolizumab
Administration route intravenous infusion
Dosage pembrolizumab, every 21 days, until disease recurrence, unacceptable toxicity, or they undergo up to 18 total cycles (approximately 1 year of treatment), whichever is sooner
Pts 50
Age Adult, Older_Adult
References PMID: 38246194

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