Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2071
Trial ID NCT03876769
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Kymriah|Tisagenlecleucel
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleStudy of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients
Year2019
CountryUnited States
Company sponsorNovartis Pharmaceuticals
Other ID(s)CCTL019G2201J|2017-002116-14
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage ≤50kg: 0.2~5E6 cells/kg; >50kg: 0.1~2.5E8 cells
Donor type Autologous
Pts 140
Age Child, Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph