Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC2025
Trial ID NCT03761056
Disease B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Generation2nd
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleStudy to Evaluate the Efficacy and Safety of Axicabtagene Ciloleucel as First-Line Therapy in Participants With High-Risk Large B-Cell Lymphoma
Year2018
CountryFrance
Company sponsorKite, A Gilead Company
Other ID(s)KTE-C19-112|2019-002291-13
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E6 cells/kg
Donor type Autologous
Pts 42
Age Adult, Older_Adult
Lymph depletion Yes

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